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None of them seem to be active in vivo [Collins 2002, Barret 2003, Ghaemmaghami & Ahn 2009]

A biomimetic drug delivery system by integrating grapefruit extracellular vesicles and doxorubicin-loaded heparin-based nanoparticles for glioma therapy

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Interfaces 8 (24), 1502415032

This would verify the recovery of definitive injuries, whatever noxious procedure, including crush [31,32], denervation [26,33], full transection [30,35,38], detachment [13,27,28], pseudoarthrosis [39], and bone loss [40,41]

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