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Melanocytes also contribute to the homeostasis of skin and oral mucosa by acting as neuroendocrine cells secreting neuropeptides and as antigen presenting cells and phagocytes [4, 6, 8, 9]

POMC-derived peptides including adrenocorticotropin (ACTH), alpha melanocyte stimulating hormone (-MSH), -MSH and -endorphins, MC1R, adrenergic and cholinergic agents, and growth factors, cytokines, or nitric oxide (NO) secreted in the local microenvironment are all involved in the regulation of melanogenesis [6]

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