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To prevent shelterin from dissociating into smaller subunits and to keep the complex intact during MP measurements, the samples were crosslinked after co-incubation with compounds, using 0.1% glutaraldehyde for 25 min at room temperature and quenched with 100 mM Tris-HCl pH 8.0 for 5 min (Supplementary Fig

An important characteristic of Cortagen is its bell-curve dose-response relationship

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