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Collectively, our results suggest that upregulation of the glutamate transporter EAAT3 is an adaptation of EBV-infected cells to maintain cellular redox homeostasis against the virus-induced oxidative stress, and that this cellular balance could be therapeutically destroyed by targeting EAAT3 to impede EBV-associated cancers

Moreover, we summarize the most advanced applications in the clinical setting, providing an overview of DNA methylation hotspots for cancer diagnosis and prognosis, as well as the impact of epidrugs on cancer care and personalized medicine

In addition, we identified, for the first time, 4-OXO-DHA in plasma of rats fed DHA

Despite third/fourth-generation engineering advances (102), translational barriers persist, necessitating systematic evaluation of ADC-immunotherapy combinations in biomarker-stratified clinical trials to fully unlock their therapeutic potential in CRC

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