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Nevertheless, there remain many challenges to overcome in order to establish the level of risk associated with environmental pollutants in interaction with gut bacteria

In this phase, studies have suggested that macrophages secrete proteases, especially matrix metalloproteinase-9 (MMP-9), to destroy elastin, fibrin, and other matrix proteins that the tension of the fibrous cap comes from, making macrophages an important player in plaque destabilization (97)

The cytokine storm is a serious and sometimes lethal consequence of CAP, caused by an overactive and dysregulated immune system

In a recent work by Corradini et al., variants of genes related to iron metabolism were shown to be associated with hyperferritinemia and more severe NAFLD (58)

doi: 10.1038/nature02046

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