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Mol Metab (2017) 6:1395406

For example, AMPK controls the expression of genes that make enzymes for glycolysis, mitochondrial function, and fatty acid synthesis [140] Activation of oncogenic signaling pathways such as PI3K/AKT/mTOR can alter metabolism, facilitating cell growth and division [107]

The authors concluded that overall, at this concentration tested, 9 g/mL, only a minimal effect on host defense peptides and pro-inflammatory cytokines were observed [189]

Subsequently, the biological effects of MK-677 were studied in 105 elderly subjects who met objective criteria for functional impairment

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