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This Introduction sets the conceptual framework for the rest of the work and justifies the need for diagnostic and therapeutic strategies that account for source, compartment and context specificity in ROS signaling

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With significant technological advancements, including mass spectrometry, chromatography, and nuclear magnetic resonance (NMR) spectroscopy, the efficiency and reliability of metabolic analysis have been improved significantly (60)

In macrophages, scoparone can alleviate lipopolysaccharide-induced immune responses partly by blocking TLR-4/NF-B signaling, and regulate autophagy by inhibiting the ROS/P38/Nrf2 axis