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By understanding the metabolic pathway disruption and other pathophysiological determinants that dismantle ferroptosis defence, this may expose druggable targets to restore metabolic flux and recover ferroptosis defences in disease contexts

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doi: 10.3389/falgy.2026.1771105 Received 18 December 2025 Revised 17 February 2026 Accepted 20 February 2026 Published 12 March 2026 Volume 7 - 2026 Edited by Hasan Bayram, Ko University, Trkiye Reviewed by Zeynep Celebi Sozener, Ankara City Hospital, Trkiye Nuray Uslu Kizilkan, Ko University, Trkiye Updates Copyright 2026 Pilat, Hiremath, Wechsler, Dellon, Choksi and Buendia

(2006a, b) demonstrated the role of Comano thermal water in the significant inhibition of intracellular TNF-alpha, resulting in the downregulation of IL-8 and IL-6 in keratinocytes, which ultimately led to the control of the abnormal differentiation of keratinocytes, opening ways to treat skin diseases with underlying abnormal differentiation of keratinocytes