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Abbreviations AA: Amino acid BCKA: Branched-chain -keto acid BCAA: Branched-chained amino acid CDX: Cell-derived xenograft H&E: Hematoxylin and eosin CDOX: Orthotopic cell-derived xenograft PDAC: Pancreatic ductal adenocarcinoma PDX: Patients-derived xenograft Pcorr: Pearson correlation coefficients PC: Primary cancer TSP: Sodium 3-[trimethylsilyl] propionate-2,2,3,3-d4 CSDX: Subcutaneous cell-derived xenograft PDXG1: The first generation of PDX tumor PDXG3: The third generation of PDX tumor TCA: Tricarboxylic acid cycle VIP: Variable importance in projections References Gengenbacher N, Singhal M, Augustin HG

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