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The primary manifestation of this condition, kidney stones, impinges upon approximately 10-15% of the global populace ( Recent research has elucidated a significant correlation between the injury of RTCs, the insurgence of calcium oxalate (CaOx) crystals presence, and the concomitant inflammatory responses and stone formation, thereby illuminating their contributory role in the pathophysiology of nephrolithiasis

Based on the position of the maximum (at pK a =7), the N-terminal Cys pK a values of Trx (55) (67) are ideal with regard to nucleophilic power (see Fig

[138,139] NAC may have a role, however, in the reversal of renal toxicity due to cisplatin

Hauser RA, Factor SA, Marder SR, Knesevich MA, Ramirez PM, Jimenez R, Burke J, Liang GS, O''Brien CF

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