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A substantial proportion of these compounds are lipophilic in nature and exhibit extremely low solubility in the aqueous environment of the gastrointestinal tract

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As presented in Figure 1 , islet-graft-confronted immune responses can be divided mainly into three types, including (1) autoimmune recurrence and alloimmunity, (2) instant blood-mediated inflammatory reaction (IBMIR), and (3) hypoxia and oxidative stress