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However, a phase II clinical trial (NCT03486223) failed to demonstrate its efficacy in treating impaired glucose tolerance, obesity and endocrine system diseases, even though it can inhibit sEH activity in plasma, muscle, and adipose tissue and reduce F2-isoprostanes, a marker of oxidative stress

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Two to six times more ynfA gene expression than tolC gene expression was observed (Sarkar et al., 2015)

Thus, the dosage in individual cases was modulated to avoid the occurrence of specific clinical side effects or blood exam abnormalities (headache and insomnia, weight changes, age, neutropenia, alteration of liver function indices, hypercholesterolemia, gastrointestinal disturbances) by adjusting to maximal dosage without side effects, as required for off-label drug administration

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Front Microbiol 13