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Animal studies further indicate that gut microbiota directly regulate the regenerative potential of the epithelium, particularly by stimulating Lgr5 + stem cells and promoting differentiation of Paneth and goblet cells

Mehra RK, Winge DR (1991) Metal ion resistance in fungi: molecular mechanisms and their regulated expression

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[DOI] [PMC free article] [PubMed] [Google Scholar] 444.Bjornevik K, et al

220,222,231,236,237 However, the challenges posed by the broad targets of autophagy modulators, and lack of appropriate in vivo autophagic flux detection methods, hinder further clinical applications of these drugs