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200 Hyperthermia is a cancer treatment method in which the tumour is heated to 4045C, initiating molecular events that render cells more susceptible to various forms of damage and cell death

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This activation upregulates the expression of key mitophagy-associated proteins, notably LC3-II, PINK1, and Parkin, ultimately driving mitophagosome formation 32

Intravenous administration would overcome these problems, as it allows instant circulation of the precursors rather than initial metabolism by the gut microbiota and liver

Fair skin tones may notice results sooner (1-3 months), while darker complexions often require 6-12 months for significant brightening

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