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Conway R, Low C, Coughlan RJ, ODonnell MJ, Carey JJ (2015) Risk of liver injury among methotrexate users: a meta-analysis of randomised controlled trials

2018;174:54963 e519

Sevarino, 2022)

doi: 10.1038/nature06664 173 BillinghamLKStoolmanJSVasanKRodriguezAEPoorTASziborMet al

Another challenge for nose-to-brain drug delivery is the development of appropriate delivery devices, since standard devices are optimized for local effects and therefore deliver only a small amount of drug to the olfactory region [65]