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Signal Transduct Target Ther (2020) 5(1):84

Approach Community research planning Duration 8-16 weeks Review Point Every 4 weeks Notes Common research-planning structure with optional review points

O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Erastin and other molecules (e.g., salazosulfapyridine, sorafenib) can induce ferroptosis by inhibiting system x and reducing GSH production (13, 30)

[7] Mitochondrial pyruvate carriers In cells with mitochondria, most of the pyruvate produced in the cytosol enters the mitochondrial matrix passing through the outer and the inner mitochondrial membranes

Notably, the level of glutamate is relatively high compared with that of GABA, caused by various etiologies, including glutamate release by damage-induced depolarization, exaggerated glutamate release through xc(), and attenuated uptake of glutamate through EAATs, or a decrease in GABA release with subsequent increase in glutamate release