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Brain sections were fixed with 4% paraformaldehyde, then washed with ethanol and incubated in filtered 1% Thioflavin-S

Porto Biomed

TLR expression varies across different host ages (136), increasing the risk of excessive inflammation in young hosts

In BMDMs, DRP1 knockdown initiated NLRP3 inflammasomal activation and IL-1 secretion, while inducing mitochondrial fission attenuated NLRP3 inflammasomal assembly and activation (165)

F.SantosH

Dysbiosis-driven aberrations in microbial composition and activity disrupt the production of these metabolites, compromising intestinal barrier integrity, fueling chronic low-grade inflammation, and exacerbating insulin resistance