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10.1016/j.lwt.2024.116083 243 RoversiD.TroianoC.SalnikovE.GiordanoL.RiccitelliF.De ZottiM.et al (2023)

Limitations of Current Evidence Several critical limitations characterize the current evidence base for these peptide therapeutics

These dioxygenases are required for the differentiation of NSCs derived from embryonic midbrains into dopaminergic neurons, where vitamin C treatment increases 5-hydroxymethylcytosine (5hmC) content and decreases H3k27m3 in promoters of dopaminergic lineage differentiation genes, such as Nurr1 ( 2+ /-KGDDs activated by vitamin C (Wang et al., 2011