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One of the widely tested drugs is Bexarotene, which is an RXR/LXR agonist that initially showed promising results in animal models of AD, increasing amyloid clearance and improving behavioral deficits [208, 209]

So I feel like its sort of an ominous dip because the drugs suck

Together, our findings link -KG to energy sensing through AMPK translation and propose that targeting -KGYBX1-dependent AMPK translation can sensitize human cancer cells to energy stress for treatment

For the control group, normal saline, which was dissolved in 2% dimethylsulfoxide (DMSO), was administered to the animal model and the treatment group, which were further separated into three different groups, were given three different doses of poncirin (5, 15 and 30 mg/kg) to identify whether the poncirin could reduce the damage caused by CCl4 administration

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Both methods are used in the pursuit of advancing knowledge in the area being studied, for example, rare diseases