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Oxidative modification of lens proteins, loss of protein function and the creation of protein aggregates of high molecular mass, which increases the scattering of light, are the main features of age-related cataract 6

Sulfasalazine and erastin are SLC7A11 and GPX4 inhibitors, respectively

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To further evaluate the functions of these overlapping target genes, 235 drug-disease intersection gene targets were filtered through the KEGG pathway

This designation provides regulatory and commercial incentives to support development for small patient populations