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In LPS-treated BV2 cells and rat primary microglia, UA inhibited the production of pro-inflammatory cytokines (e.g., NO, TNF-, and PGE2) to shield dopaminergic neurons from the toxic effects of activated microglia

Norman JG

Bokulic, A

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2 Mitochondria dysfunction as primary damage post-traumatic brain injury Mitochondrial dysfunction refers to mitochondria failing to perform one of their critical functions: sensing, integration, or signaling (Picard and Shirihai, 2022)