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Labwork at that time was notable for an elevated uric acid of 10.6mg/dl (reference range: 3.5 - 8.5 mg/dl.) Out of concern for TLS precipitating hyperuricemia in the setting of a high-grade tumor in addition to starting a new chemotherapy regimen, the patient was additionally given 10mg of rasburicase and started on 300mg of allopurinol daily

J Neurosci 26(10):28142819 Jin S, Wu J, Wang C, He Y, Tang Y, Huang L, Zhou H, Liu D, Wu Z, Feng Y, Chen H, He X, Yang G, Peng C, Qiu J, Li T, Yin Y, He L (2025) Aspartate metabolism-driven gut microbiota dynamics and rip-dependent mitochondrial function counteract oxidative stress

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10.1038/nrc3711 25 BiswasS

For example, gemcitabine thermosensitive hydrogels or microspheres are used for intraperitoneal perfusion to treat peritoneal metastasis, which can form a drug sustained release reservoir in the peritoneal cavity, prolong local exposure time and reduce systemic toxicity (Xu et al., 2016)