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Description

The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma

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The combination is researched because of different receptor targets (activates both GHRH-R and GHSR pathways), synergistic effect (combined GH release may be 5-10x greater than either alone), complementary actions (CJC-1295 primes GH synthesis