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In hepatic cells, phosphorylated HSP27 promotes autophagy and lipid clearance, suggesting its therapeutic potential in MASLD and non-alcoholic steatohepatitis (NASH), now referred to as metabolic dysfunction-associated steatohepatitis (MASH)

This suggests that glutamate metabolism is also compartmentalized in osteoclasts with glutamine providing mitochondrial glutamate for mitochondrial transaminases like GOT2

Glutathionylation of C23 (peptide VVVFIKPT C PYCR), and C8 (peptide MAQEFYN C K) was readily detectable following incubation with 1 mM GSSG, while glutathionylation of C79 and C83 (peptide D C IGG C SDLISMQQTGELMTR) was more prominently detected in response to 50 mM GSSG

Mirzaei, Application of quercetin in the treatment of gastrointestinal cancers