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This results in a short-acting and well-controlled profile , which is ideal for precise research designs

The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage

10.1111/j.1365-2982.2008.01108.x 139 SavalliN.PantazisA.SiggD.OlceseR

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and acylcarnitine increased from 16.8 9.1 mol/L to 17.3 9.8 mol/L, showing an upward trend (Figure 5)