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An unrelated modulator of mitochondrial function not predicted to directly affect Gin metabolism, dichloroacetic acid (DCA), had no effect on erastin-induced ferroptosis (FIG

In fact, each of the above-mentioned aberrations and/or combinations thereof may induce specific F&S symptoms, whereas ME/CFS is associated with the more severe forms of IO&NS aberrations (for example, severe inflammation, dysregulation of the RNase L pathway, apoptosis pathways, persistent damage to membrane lipids, functional proteins, DNA, and mitochondria and autoimmune responses [4, 20])