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Research has demonstrated that glutamate dehydrogenase (GLUD1) is expressed at a high level in lung adenocarcinoma cells, and lysine 503 (K503) has been identified as the primary ubiquitination site of GLUD1

When the kidneys are damaged, they produce less erythropoietin (EPO), which is a hormone that tells your bone marrow to produce red blood cells

Moreover, recent clinical studies have shown that HCM-causative FHOD3 mutations increase the risk of cardiovascular death and all-cause death, with the onset of the disease occurring as early as age 4 and as late as age 63 (Vodnjov et al., 2023

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Other studies indicate that lower serum IGF-1 concentrations are associated with reduced cognitive function, showing a negative correlation with age, disease duration, and modified Rankin Scale [134, 135], yet a positive association with more substantial declines in Minimum Mental State Examination (MMSE) scores, CSF A 1-42 /A 1-40 ratio, and diminishing recall, language fluency, attention, and numeracy function [134, 136]

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