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Dysfunctional TJs have been discovered in coeliac patients and potentially contributes to intestinal leakage providing an access route for gliadin to the underlying immune system in the lamina propria (Schulzke et al

The SCFA butyrate has been shown to decrease bacterial translocation and strengthen intestinal barrier function 24

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Self-assembly of nanoparticles into structured spherical and network aggregates

Both are BCMA-directed, meaning that the patients T cells are collected, altered so that they can recognize BCMA on the surface of myeloma cells, and infused back into the patient, where they kill the myeloma cells