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465,466,467,468 In RA, mitochondrial dysfunction drives chronic synovial inflammation despite preserved mitochondrial mass

& Stepie, M

However, when inflammation becomes chronic, it contributes to the development and progression of various diseases [17]

This can be attributed to the increase in the net negative and positive charges as the pH deviates from the isoelectric point, which promotes intermolecular repulsion, enhances the dispersive ability, and ultimately increases protein solubility (32)

However, further large-scale, well-controlled studies are needed to confirm its efficacy and to determine optimal dosing strategies

Trends Cardiovasc Med