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However, in tauopathies such as AD, as well as in hibernation, tau undergoes hyperphosphorylation catalyzed by various protein kinases, including but not limited to glycogen GSK3, cyclin-dependent kinase 5 (CDK5), and protein kinase A (PKA) [103,104,105], accumulating an excess of 7-10 phosphate groups [106]

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On the other hand, animals immunized with pCTV-WS had maintained tissue architecture and only discrete inflammatory infiltrate (black arrow), perivascular inflammatory infiltrate (red arrow) and alveolar septal thickening (yellow arrow) (Fig

That addition of oxygen is structurally changing it into something else