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Poster Session I - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P390 - ESOC25-2087 Santiago Clocchiatti-Tuozzo 1 , Cyprien Rivier 1 , Shufan Huo 1 , Ashkan Shoamanesh 2 , Hooman Kamel 3 , Santosh Murthy 3 , Adam de Havenon 1 , Lauren Sansing 1 , Thomas Gill 1 , Kevin Sheth 1 , Guido Falcone 1 1 Yale School of Medicine, New Haven, United States, 2 Faculty of Health Sciences, McMaster University, Hamilton, Canada, 3 Weill Cornell Medicine, New York, United States Background and Aims: Randomized controlled trials (RCTs) are the gold standard for evaluating treatment effects but are costly and time-consuming