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In pregnant and breastfeeding women, vitamin B12 deficiency might cause neural tube defects, developmental delays, failure to thrive, and anemia in offspring

TRPC6 is also expressed in these erythrocytic progenitor cells [99], and in humans, erythrocytes TRPC6 accomplishes Ca 2+ influx [100] in contrast to mouse erythrocytes, where TRPC4/5 are involved [101]

Vallires C, Golinelli-Cohen MP, Guittet O, Lepoivre M, Huang ME, Vernis L

Individual response varies considerably, with some noticing effects earlier than others

Research Square Preprint2023 Aug 18

J Inherit Metab Dis 28:818, PMID: 15702408 Pastore A, Petrillo S, Tozzi G, Carrozzo R, Martinelli D, Dionisi-Vici C, Di Giovamberardino G, Ceravolo F, Klein MB, Miller G, Enns GM, Bertini E, Piemonte F (2013) Glutathione: a redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies