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P = 0.3167)

Meanwhile, the unsaturated alkyl chain accelerates the dissociation of PEG (ceramide-PEG vs DPG-PEG), while the neutral and anionic PEG-lipids (DPG-PEG vs DPPE-PEG

The initial condition was set at 99% B, linearly decreasing to 70% B from 0.5 min to 4.0 min, and 1% B from 4.0 min to 6.5 min, and was then maintained at 1% B for 2.5 min

Future studies should incorporate models with greater human relevance, including humanized mouse systems and patient-derived organoids, to more reliably evaluate drug exposure, toxicity and lactylation-dependent signaling

Its solubility is affected by factors such as temperature and the type of solvent