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Neuromuscular disease Myopathy can be seen with biochemically defined defects in mitochondrial substrate transport or utilization, including the myopathic form of carnitine deficiency

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Dogs with the ACE variant had lower levels of ACE activity even in more advanced mitral valve disease than dogs without the variant." They concluded that the impact of their finding "on the need for ACE-I in dogs with the polymorphism and heart disease deserves further study." Then, in a September 2023 abstract, the same authors' aim was to determine the impact of certain angiotensin converting enzyme (ACE) gene polymorphisms upon the presence of congestive heart failure (CHF) in MVD-affected cavaliers

Figure 6 To further elucidate whether these alterations in mitochondrial Ca 2+ retention capacity were due to changes in cyclophilin D or MCU, we developed western blots for these two proteins

Garcia in "The NT-proBNP assay: A portent of heart health." in dvm360: "For conditions such as mitral valve disease, this test may be of limited value because a diagnosis can be readily made by thorough auscultation and documentation of a heart murmur