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Briefly, cells and tumor tissues from treated (with R001) or untreated (DMSO, control), were collected and homogenized in the equivalent volume of ice-cold PBS and centrifuged at 15,000 g for 10 min to remove insoluble materials

For identification of a potent SAMiRNA for AR silencing, 547 SAMiRNA candidates were synthesized and screened

it attenuates damaging effects of ROS in the cells and improves the stability of the mRNA [47]

The von Hippel-Lindau (VHL) gene acts as a major tumor suppressor in ccRCC

The MSNs-based therapeutic nanoplatform can realize enhanced anti-tumor efficacy by releasing chemotherapeutic drugs for the enhanced catalytic generation of ROS

A.|Bjugstad, K