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UPR is associated with three ER transmembrane receptors: protein kinase R-like endoplasmic reticulum kinase (PERK), activating transcription factor 6 (ATF6) and inositol-requiring kinase 1 (lRE1) in mammalian cells (Szegezdi et al., 2006)

Funding This research was supported by Luzhou's major scientific and technology research and development project (nos.2022-SYF-42), Luzhou Municipal People's GovernmentSouthwest Medical University Science and Technology Strategic Cooperation Climbing Plan Project, (2021LZXNYD-D02), Joint Innovation Special of the Sichuan Provincial Science and Technology Plan (nos.2022YFS0609/2022YFS0609-B3), the Sichuan Science and Technology Department Project Development Project(nos

With respect to epigenetic regulation, CTBP functions as a transcriptional repressor by associating with nucleosome remodeling and the deacetylase (NURD) complex 148 , class II HDACs (HDAC4/5/7/9) 178 , and COREST (co-repressor of REST), which includes HDAC1/2 and LSD1, and removes acetyl groups and H3K4 monomethylation/dimethylation from nucleosomes, leading to transcriptional repression 179 (Fig

It helps eliminate toxins and harmful substances from the body, promoting the proper functioning of detoxification organs such as the liver and kidneys

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