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Disclosures: Teiji Kuzuya: Chugai Pharmaceutical Co: Speaking and Teaching, Eisai: Speaking and Teaching, Eli Lilly Japan: Speaking and Teaching, AstraZeneca: Speaking and Teaching, Naoto Kawabe: Nothing to Disclose, Yoshiki Hirooka: Nothing to Disclose 1822 A COMPARATIVE VALIDATION OF CLINICAL PREDICTION SCORES FOR HEPATOCELLULAR CARCINOMA IN STEATOTIC LIVER DISEASE WITHOUT CIRRHOSIS Catherine Mezzacappa 1 Janet Tate 1 Tamar Taddei 1 Amy Justice 1 , 1 Yale University Background: Many clinical risk scores to predict hepatocellular carcinoma (HCC) have been assessed in cohorts without known cirrhosis or viral hepatitis, whose HCC risk is driven by steatotic liver disease (SLD)

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Oxidative stress and cartilage damage Oxidative stress is also an important mechanism causing cartilage damage

Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease