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Pathobiology 67 , 253256 (1999)

Cell 167 , 457470.e413 (2016)

Targeted experimental validation was performed in murine myotubes/muscle tissue from mALD for mitochondrial oxidative function using high sensitivity respirofluorometry, structural evaluation of mitochondrial morphology using confocal microscopy, cristae morphology on 3D electron microscopy, HIF1a, and myostatin expression by immunoblots

In MODS induced by heat stress, the liver is one of the earliest organs damaged (Fig