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Pharmacokinetic indices of glucosamine were determined using the non-compartmental analysis section of WinNolin version 3.1 (Pharsight Corporation, CA, USA)

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Lei et al., 2021

Gut microbes and their metabolites have profound effects on immune and neurological homeostasis, influencing the development and function of multiple physiological systems

These include the increased biosynthesis short-chain fatty acids, digestive enzymes, enlarged size of intestinal villi, increased level of enterocytes, improvement of the immune function, modulation of the presence of intestinal microorganisms, and suppressing the growth of pathogenic microorganisms and microbial hemostasis in the gut, and the reduction of triglycerides and cortisol (de Jesus Raposo et al., 2016)