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This imbalance is usually caused by an excessive accumulation of ROS, which are oxygen-containing molecules produced during cellular metabolism that are highly reactive (Lee et al., 2021)

Materials (Basel) 17:117 Re R, Pellegrini N, Proteggente A et al (1999) Antioxidant activity applying an improved ABTS radical cation decolorization assay

Blood or CSF lactate and pyruvate are elevated with normal lactate to pyruvate (L/P) ratio (reference range: 10 to 20), differentiating primary pyruvate dehydrogenase complex deficiency from primary mitochondrial disorders, such as those due to electron transport chain dysfunction where L/P ratios are generally elevated

EGCG EGCG, the key antioxidant in green tea, supports metabolic balance, cardiovascular health, and cellular detoxification

Preclinical studies have described the role of Vitamin E in AD: it seems to reduce transepidermal water loss (TEWL), which is associated with AD pathogenesis, and to induce the expression of the transglutaminase-1 gene, involved in terminal differentiation of keratinocytes and in the formation of the stratum corneum (8385)

Fractional laser resurfacing produces excellent outcomes with minimal recovery time