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Enhancing fatty acid utilization ameliorates mitochondrial fragmentation and cardiac dysfunction via rebalancing optic atrophy 1 processing in the failing heart

The change in UPDRS score from baseline to final visit was used as the primary outcome to assess improvements following supplementation

Since ROS are short-lived molecules, the transcriptional activation of antioxidant enzymes can serve as a marker of defense against elevated intracellular ROS levels

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The contribution of OS to atopic dermatitis is likely related to the infiltration of the skin with inflammatory cells and cytokines, which promote ROS formation and disrupt the skins antioxidant barrier [197,199,200]

This was as evidenced by decreased expression of VE-cadherin, a protein crucial for cell junction maintenance, and disrupted localization of VE-cadherin at cellcell contacts after Mn exposure