is cagrilintide a glp-1 + T (1+10mg) Cagrilintide (2.5mg) / GLP-1 S

Mechanism of Action (MOA): Inhibit the DPP-4 enzyme, preventing the breakdown of endogenous GLP-1, leading to: Glucose-dependent insulin secretion Glucose-dependent glucagon secretion Efficacy: HbA1c reduction: 0.6%0.8% Primarily reduces postprandial glucose Common Dosing: Sitagliptin (Januvia): 100 mg once daily (dose adjustment required in renal impairment) Saxagliptin (Onglyza): 5 mg once daily ( dose in renal impairment) Linagliptin (Tradjenta): 5 mg once daily (no renal or hepatic dose adjustment) Alogliptin (Nesina): 25 mg once daily ( dose in renal impairment) Adverse Effects: Generally placebo-like URTI, headache, mild GI upset Advantages: Weight neutral Suitable for patients with renal impairment (with dose adjustment) Well-tolerated Possible -cellsparing effect Disadvantages: Risk of acute pancreatitis Joint pain Saxagliptin & alogliptin: potential risk of heart failure Precautions: History of pancreatitis Not recommended in DKA Not indicated in Type 1 Diabetes Monitor for heart failure (saxagliptin, alogliptin) #DPP4Inhibitors #Type2Diabetes #ClinicalPharmacy #Pharmacology #MedicationSafety #DiabetesCare #Endocrinology #PharmacyEducation #HealthcareProfessionals To view or add a comment, sign in 3,206 followers

As nutrient-rich fluids replenish and restore your body from within, your skin is cleansed, exfoliated, and infused with hydrating, age-defying serums for a luminous glow

But when we think about risk and benefit, the risk is if youve got low-grade inflammation, youve got early signs of cancer happening, are you going to overload that pathway and promote that cancer to grow bigger, faster? Taylor said

Celikten M

The key differences are subtle

Gastrointestinal health improves because the molecule protects against oxidative stress and ulceration