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The GSH and GSSG amount was evaluated using GSH/GSSG assay kit

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

Potential suspects, including environmental or industrial toxins, heavy metals, and illicit drugs, have been considered, but none have been conclusively implicated

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However, ligand density and spatial arrangement must be carefully optimized to avoid receptor saturation or reduced binding efficiency