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The accumulation of succinate inhibits prolyl hydroxylases, reinforcing HIF-1 stability, and can drive mitochondrial reverse electron transport to generate ROS that activate the NLRP3 inflammasome (47, 66)

20 Ubiquitin harbors eight sites available for ubiquitination, including seven internal lysine (Lys, K) residues (K6, K11, K27, K29, K33, K48, and K63) and the -amino group of the N-terminal methionine (M1), which contribute to the formation of distinct homotypic polyubiquitin chains and their unique topologies

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It is used in aesthetic medicine to stimulate skin repair and regeneration