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Consent for publication The authors give their consents for the publication of contents of this paper to be published in the Cellular and Molecular Life Sciences

The mutant fragments were cloned into pK18, a suicide vector, to generate gene knockout plasmids

Clinical and experimental evidence confirms a U-shaped relationship between copper levels and blood pressure, indicating that both copper deficiency and excess are associated with a higher prevalence of hypertension [213]

Before a lyophilized medication can be administered, it needs to be reconstituted, which is the process of mixing it in bacteriostatic water so that it can be injected

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Epstein, The role of proteolytic cellular systems in trabecular meshwork homeostasis