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doi: 10.3389/fphar.2022.1071897 Received 17 October 2022 Accepted 16 November 2022 Published 24 November 2022 Volume 13 - 2022 Edited by Chunpeng (Craig) Wan, Jiangxi Agricultural University, China Reviewed by Hui Wang, University of Massachusetts Medical School, United States Fei Yuan, Baylor College of Medicine, United States Updates Copyright 2022 Zhang, Lei, Huang and Wang

doi: 10.1007/BF00400095 39 ZhangX.ZhaoY.ZhangM.PangX.XuJ.KangC.et al

Acknowledgements This work is supported by the National Natural Science Foundation of China (22172008, L.F

Fumarate, also an intermediate metabolite of the TCA cycle, conventionally links arginine metabolism to glucose-generated energy metabolism

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Thus, ExerVs may represent a novel approach to ensure protection of human health during spaceflight or conditions that lead to significant muscle atrophy during periods of disuse