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More help Biological Plausibility Addresses the biological rationale for a connection between KEupstream and KEdownstream

Nat Rev Microbiol 16(3):156170 Hallett RL et al (2004) Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes

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Therefore, it could be hypothesized that until oxygen becomes limiting for FIH, NF-B regulates tumor cell growth and expansion through pyruvate-mediated competitive inhibition of PHD-2 (Figure 8)

Modulates expression of over 4,000 genes involved in tissue remodeling, including upregulation of collagen, elastin, and glycosaminoglycan synthesis

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