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Scaffold Repurposing of in-House Chemical Library toward the Identification of New Casein Kinase 1 delta Inhibitors

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Additionally, when vitamin C is incubated with peripheral blood lymphocytes in vitro, it reduces the production of various inflammatory cytokines, such as TNF- and IFN-, induced by lipopolysaccharide, whilst increasing the production of the anti-inflammatory cytokine IL-10 (50)

It is now well established that CFTR functions as a cyclic adenosine monophosphate (cAMP)-dependent Cl channel in the apical membrane of secretory epithelia

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In patients with osteosarcoma, which is the most common bone tumor, serum, and urinary metabolomics revealed a distinct phenotype compared to healthy patients, suggesting that downregulation of central carbon metabolism and increased glutathione metabolism were characteristic features of osteosarcoma 14