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A plausible explanation could be a reorientation of Lys105 towards GS resulting in a decreased stabilization of the active site thiolate as a leaving group

This modification, known as an omega-amino acid modification, may help improve the peptides resistance to enzymatic degradation

Journal of Clinical Gastroenterology, 51 (1), e5-e10

In a tightly controlled feedback loop, progesterone then limits expression of ER-alpha via PR-A (McDonnell and Goldman, 1994)

25 Hydrogels can be synthesized in a number of ways, including one-step or multistep procedures

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