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Experts Recommendations for Therapeutic Landscapes The extended use of metformin, a key player in preventing type 2 diabetes among individuals with prediabetes, has been associated with vitamin B 12 deficiency, particularly concerning for specific subgroups such as those with a BMI of 35 kg/m 2 , individuals below the age of 60, and women with prior gestational diabetes mellitus [46]

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Any signs of difficulty breathing, swelling, or rash should be treated as urgent

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Thus, Cetilistat acts more like a detergent, whereas orlistat may promote the coalescence of micelles, leading to oil-drops and increased gastrointestinal adverse events